Medical Writers News Hubb
Advertisement Banner
  • Home
  • News
  • Papers
  • Contact
No Result
View All Result
  • Home
  • News
  • Papers
  • Contact
No Result
View All Result
Wellnessnewshubb
No Result
View All Result
Home News

MicroRNAs can upregulate proteins in addition to downregulating protein production

admin by admin
November 10, 2022
in News



microRNAs can play a role in cancer development and are thought to exclusively suppress protein expression in dividing cells, such as tumor cells. But new research published in ACS Central Science shows that some of these tiny molecules can elevate the expression of a particular gene in dividing human cells and in cancer cells, challenging conventional wisdom.

Only a few nucleotides in length, microRNAs, or miRNAs for short, don’t encode proteins. Instead, they largely downregulate, or suppress, protein production by silencing the expression of certain genes. One class of cellular machinery regulated by miRNAs are the enzymes involved in mediating glycosylation, which add carbohydrates to certain proteins. In cancer cells, however, this process can be highly dysregulated, suggesting that miRNAs could be doing something unusual. So, Lara Mahal and colleagues set out to investigate exactly how miRNAs function within the glycosylation process, and whether the molecules might be functioning in a new way.

Previously, the researchers developed a fluorescence assay that can analyze how miRNAs interact with their targets, and whether they increase or decrease the amount of protein produced. They used the assay to investigate the regulation of cancer-related glycosylation enzymes ST6GAL1 and ST6GAL2, and found that for the former, the miRNAs appeared to directly upregulate the process in noncancerous human cells. This challenges the current understanding that miRNAs only downregulate protein production. They also tested for miRNA-mediated upregulation in multiple cancer cell lines and observed the same results. The researchers say that this work expands the understanding of how miRNAs work, an important consideration for using miRNA-based therapeutics in both current and future clinical trials.

Source:

American Chemical Society

Journal reference:

Jame-Chenarboo, F., et al. (2022) High-Throughput Analysis Reveals miRNA Upregulating α-2,6-Sialic Acid through Direct miRNA–mRNA Interactions. ACS Central Science. doi.org/10.1021/acscentsci.2c00748.



Source link

Tags: AssayCancerGeneGenesGlycosylationNucleotidesProteinProtein ExpressionResearchTumor
Previous Post

Dissolvable devices using liquid metal embrittlement

Next Post

Donatelle expands clean room capacity

Next Post

Donatelle expands clean room capacity

Recommended

Pathogenicity of SARS-CoV-2 viral components on human periodontal tissues and cells

1 month ago

Glowing nanoparticles enhance at-home COVID-19 test sensitivity

2 weeks ago

Organic Farming And Phytonutrients

7 months ago

Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

3 weeks ago

Report of a case of severe tick-borne encephalitis in a pregnant woman

1 month ago

NFL has been slow to embrace mental health support for players

2 months ago
Medical-Writers-(-white-)

© Medical Writers News Hubb All rights reserved.

Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Privacy Policy and Terms & Conditions.

Navigate Site

  • Home
  • News
  • Papers
  • Contact

Newsletter Sign Up.

No Result
View All Result
  • Home
  • News
  • Papers
  • Contact

© 2022 Medical Writers News Hubb All rights reserved.